(一)GC抵抗的概念

GC抵抗是指患者对大剂量GC治疗疗效很差或无效。

(二)GC抵抗的分类

①按是否有家族史可分为遗传性和获得性，l前者如家族性GC抵抗综合症，l但大多数GC抵抗是后天由多种内外因素作用所产生。②按GC抵抗所累及的范围可分为组织特异性GC抵抗和泛发性GC抵抗。

引自：i

Joffe1M1M，lLove1LA，lLeff1RL，let1al.Drug1therapy1of1the1idiopathic1infla1m1matory1my1opathies：ipredictors1of1response1to1predmisone1azathioprine1and1a1comparison1of1their1efficacy.Am1J1Med，l1993，l94：i379～387

Shahidi1H，lVottero1A，lStratakis1CA，let1al.Imbalanced1expression1of1the1glucocorticoid1receptor1is1of1or1ms1in1cultured1lymphocytes1from1a1patient1with1systemic1glucocorticoid1resistance1and1chronic，llymphocytic1leuke1mia.Bioche1m1Biophys1Res1Commun，l1999，l254：i559～565